Research area and keywords of research:
Instrumental Organic Chemistry
(Keywords: Mass spectrometry, HPLC, HPLC/MS/MS)
Name of the researcher(s) and research group:
- Dr. József Jekő, PhD
Name of the Institute:
University of Nyíregyháza, Institute of Environmental Science
Research objectives:
Determination of chemical profiles of different plant extracts by HPLC-MS/MS. Mass spectrometry of stable spin labelled componds.
Description and results of research:
My cooperation is geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of different plant extract (solvents: ethyl acetate, methanol, and water). The chemical profiles of the extracts are characterised by HPLC-MS/MS:
A multidirectional investigation of stem bark extracts of four African plants: HPLC-MS/MS profiling and biological potentials. HPLC-MS/MS chemical characterization and biological properties of Origanum onites extracts. Investigation of chemical profile, biological properties of Lotus corniculatus L. extracts and their apoptotic-autophagic effects on breast cancer cells. Metabolomic profile of Salvia viridis L. root extracts using HPLC–MS/MS technique and their pharmacological properties. A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties. HPLC-MS analysis of the active ingredients of chamomile (Matricaria chamomilla) bee feeding syrup. Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials. HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata.
Mass spectrometry of substituted Pyrrolidine Nitroxide radicals and paramagnetically modified heterocycles.
Research partners from other institutions:
Gokhan Zengin, PhD (associate professor), Selcuk University, Department of Biology, Konya, Turkey
Prof. Tamás Kálai, University of Pécs (Hungary)
Dr. Zoltán Cziáky, Agricultural and Molecular Research Institute of University of Nyíregyháza (Hungary)
Other information:-
Publications (max. 5):
- L. Columbus, T. Kálai, J. Jekő, K. Hideg and W.L. Hubbell: Molecular Motion of Spin Labeled Side Chains in a-Helices: Analysis by Variation of Side Chain Structure, Biochemistry, 40, 3828-3846 (2001)
- B. Bognár, M.L. Kuppusamy, E. Madan, T. Kálai, M. Balog, J. Jekő, P. Kuppusamy and K. Hideg: Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents, Medicinal Chemistry, 13(8), 761-772 (2017)
- G. Zengin, A. Uysal, A. Diuzheva, E. Gunes, J. Jekő, Z. Cziáky, C.M.N. Picot-Allain and M. F. Mahomoodally: Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight, J. Pharm. Biomed. Anal., 160, 374-382 (2018)
- G. Zengin, A. Diuzheva, J. Jekő, Z. Cziáky, G. Bulut, A. Dogan, M.Z. Haznedaroglu, K.R.R. Rengasamy, D. Lobine, M.B. Bahadori and M.F. Mahomoodally: HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentate, Industrial Crops & Products, 124 (2018) 699–706
- G. Zengin, F. Mahomoodally, C. Picot-Allain, A. Diuzheva, J. Jekő, Z. Cziáky, A. Cvetanović, A. Aktumsek, Z. Zeković, K. R.R. Rengasamy: Metabolomic profile of Salvia viridis L. root extracts using HPLC–MS/MS technique and their pharmacological properties: A comparative study, Industrial Crops & Products, 131 (2019) 266–280